Querol J R, Marse J T, Bru A D, Duran J G, Comulada J, Mitja J, Gomez J M
Rev Rhum Mal Osteoartic. 1976 Jun;43(6):411-8.
The authors analyse 7 cases which presented the criteria of ankylosing spondylarthritis and HLA 27 positivity, together with those of defined or classical rheumatoid polyarthritis with positive results in the latex test and the Waaler-Rose reaction in the joint fluid and/or the serum. The sex distribution, 6 men and 1 woman, was the same as for that disease. The clinical manifestations were very variable, with a predominance of localized, peripheral oligoarthritis in the lower limbs. Repeated iritis occurred in three cases. Two presented subcutaneous nodules on the elbow. All cases showed bilateral sacroiliitis; syndesmophytosis was rare. The overall clinical picture indicated rather a combined spondylarthritis than pure spondylarthritis. It is suggested that the occurrence of spondylarthritis in a subject with the HLA 27 gene might modify the response to the etiological factors of rheumatoid arthritis. These cases may thus be considered as a new type of combined or secondary spondylarthritis.
作者分析了7例符合强直性脊柱炎标准且HLA 27呈阳性的病例，以及那些在关节液和/或血清中乳胶试验和瓦勒 - 罗斯反应呈阳性的明确或典型类风湿性多关节炎病例。性别分布为6名男性和1名女性，与该疾病相同。临床表现差异很大，以下肢局限性、外周寡关节炎为主。3例出现反复虹膜炎。2例肘部有皮下结节。所有病例均表现为双侧骶髂关节炎；韧带骨赘少见。总体临床表现表明更像是一种合并性脊柱炎而非单纯性脊柱炎。有人提出，携带HLA 27基因的个体发生脊柱炎可能会改变对类风湿性关节炎病因因素的反应。因此，这些病例可被视为一种新型的合并性或继发性脊柱炎。
