Rodier J F, Millon R, Janser J C, Rodier D, Velten M, Pusel J, Eber M, Abecassis J
Department of Surgical Oncology, Paul Strauss Cancer Center, Strasbourg, France.
Surg Gynecol Obstet. 1993 Oct;177(4):352-6.
Gradual tumor tissue devascularization during mastectomy is thought to decrease estrogen (ER) and progesterone (PgR) receptor activity. To determine whether or not hormone receptor values could be influenced by different mastectomy techniques, 62 patients with carcinoma of the breast had a Tru-cut needle (Baxter Healthcare Corporation) biopsy (premastectomy sample) and underwent modified radical mastectomy (postmastectomy sample) either before (group 1, 40 patients) or after (group 2, 22 patients) axillary lymph node dissection. When the two surgical procedures were compared in 33 patients in whom it could be assessed, no significant tendency (p = 0.51 for ER and p = 0.36 for PgR) for the postmastectomy sample to have hormone receptors levels less than samples taken at biopsy was detected. Overall, in the two groups (44 assessable patients), comparison with respect of each patient, between premastectomy and postmastectomy samples showed that the variations in either ER or PgR receptor values, determined by immunoenzymatic assays, were not statistically significant (p = 0.32 for ER and p = 0.21 for PgR). The current results indicated the relative stability of steroid receptors during the two modified radical mastectomy procedures and suggested that a systematic reference determination of hormone receptors on biopsy before modified radical mastectomy is unnecessary.
乳房切除术期间肿瘤组织逐渐缺血被认为会降低雌激素（ER）和孕激素（PgR）受体活性。为了确定激素受体值是否会受到不同乳房切除技术的影响，62例乳腺癌患者在改良根治性乳房切除术前行Tru-cut针（百特医疗保健公司）活检（乳房切除术前样本），其中40例患者在腋窝淋巴结清扫术前（第1组），22例患者在腋窝淋巴结清扫术后（第2组）接受改良根治性乳房切除术（乳房切除术后样本）。在33例可评估的患者中比较这两种手术操作时，未检测到乳房切除术后样本的激素受体水平低于活检时样本的显著趋势（ER为p = 0.51，PgR为p = 0.36）。总体而言，在两组（44例可评估患者）中，对每位患者的乳房切除术前和术后样本进行比较显示，通过免疫酶法测定的ER或PgR受体值的变化无统计学意义（ER为p = 0.32，PgR为p = 0.21）。目前的结果表明在两种改良根治性乳房切除手术过程中类固醇受体相对稳定，并提示在改良根治性乳房切除术前对活检样本进行激素受体的系统对照测定并无必要。
