Ruitenberg E J, Steerenberg P A
Tijdschr Diergeneeskd. 1976 Jul 15;101(14):775-8.
The effect of pretreatment of intravenously administered killed Corynebacterium parvum (CP) and living BCG was studied in various model systems. Both vaccines caused an increased resistance to Listeria monocytogenes, indicating macrophage activation. Only CP exerted a suppressive effect on T-cell-mediated immunological phenomena (skin allograft survival; antibody production to tetanus toxoid; expulsion of adult T. spiralis worms from intestine). Results of experiments with congenitally athymic (nu/nu) mice and their heterozygous thymus-bearing (+/nu) littermates indicated that CP can induce macrophage activation in the absence of functional T-cells, whereas BCG-induced stimulation is a T-cell-dependent phenomenon.
在各种模型系统中研究了静脉注射灭活细小棒状杆菌（CP）和活卡介苗（BCG）预处理的效果。两种疫苗均增强了对单核细胞增生李斯特菌的抵抗力，表明巨噬细胞被激活。只有CP对T细胞介导的免疫现象（皮肤同种异体移植存活；破伤风类毒素抗体产生；从肠道驱除成年旋毛虫）具有抑制作用。对先天性无胸腺（nu/nu）小鼠及其杂合有胸腺（+/nu）同窝小鼠的实验结果表明，CP可以在没有功能性T细胞的情况下诱导巨噬细胞激活，而BCG诱导的刺激是一种T细胞依赖性现象。
