卡介苗预处理对正常和先天性无胸腺（裸）小鼠单核细胞增生李斯特菌感染病程的影响。
Effect of pretreatment with Bacillus Calmette-Guerin on the course of a Listeria monocytogenes infection in normal and congenitally athymic (nude) mice.
作者信息
Ruitenberg E J, Van Noorle Jansen L M, Kruizinga W, Steerenberg P A
出版信息
Br J Exp Pathol. 1976 Jun;57(3):310-5.
Abstract
The effect of pretreatment with BCG on the course of a Listeria monomcytogenes infection was studied in nu/nu mice and in their heterozygous littermates (+/nu). First, evidence was presented that the nu/nu mice used lacked functional T cells, since BCG treatment resulted only in skin reactivity to tuberculin in +/nu mice and not in nu/nu mice. Acquired resistance to Listeria (based on lower spleen counts) was only obtained in BCG pretreated +/nu mice. Evidence was presented that BCG pretreatment in nu/nu mice failed to increase non-specific resistance, both in terms of spleen counts and survival rate. These results seem to imply that functional T cells are required for this type of non-specific resistance to heterologous antigens. In this connection attention has been drawn to the possible implication of BCG treatment in man.
摘要
在无胸腺裸鼠（nu/nu）及其杂合子同窝小鼠（+/nu）中研究了卡介苗预处理对单核细胞增生李斯特菌感染病程的影响。首先，有证据表明所使用的无胸腺裸鼠缺乏功能性T细胞，因为卡介苗处理仅使+/nu小鼠产生对结核菌素的皮肤反应，而无胸腺裸鼠则无此反应。对李斯特菌的获得性抵抗力（基于较低的脾脏菌数）仅在经卡介苗预处理的+/nu小鼠中获得。有证据表明，无论从脾脏菌数还是存活率来看，无胸腺裸鼠的卡介苗预处理均未能增加非特异性抵抗力。这些结果似乎意味着这种对异源抗原的非特异性抵抗力需要功能性T细胞。就此而言，已有人关注卡介苗治疗对人类的潜在影响。
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