Wermke W, Borges A C
Klinik für Innere Medizin, Universitätsklinikums Charité, Medizinische Fakultät, Humboldt-Universität, Berlin.
Ther Umsch. 1993 Aug;50(8):541-6.
There are two types of gallstones: cholesterol and pigment stones. The pathogenesis is divided into three phases: supersaturation, nucleation and stone growth. Hypersecretion of biliary cholesterol, crystallization promoting and inhibiting factors, gallbladder hypomotility, arachidonyl lecithin, prostaglandins, mucin and calcium play an important role in the formation of gallstones. For the formation of pigment stones a decreased secretion of biliary acids, an increased secretion of unconjugated bilirubin into the bile and an infection of the biliary tract are the most important causative factors.
胆固醇结石和色素结石。其发病机制分为三个阶段：过饱和、成核和结石生长。胆汁胆固醇分泌过多、结晶促进和抑制因子、胆囊运动功能减退、花生四烯酰卵磷脂、前列腺素、粘蛋白和钙在胆结石形成中起重要作用。对于色素结石的形成，胆汁酸分泌减少、未结合胆红素分泌到胆汁中增加以及胆道感染是最重要的致病因素。
