Méndez-Sánchez N, Cárdenas-Vázquez R, Ponciano-Rodríguez G, Uribe M
Departmento de Gastroenterologia, Instituto Nacional de la Nutrición, México, D.F.
Arch Med Res. 1996 Winter;27(4):433-41.
The purpose of the present paper is to review the current knowledge about cholesterol gallstone disease. It is generally accepted that the formation of cholesterol gallstone requires three major pathogenic defects, namely, supersaturation, nucleation and crystal growth as well as disorder of gallbladder motility. The supersaturation is necessary but not sufficient to explain stone formation. It has been suggested that nucleation is the key factor for gallstone formation. However, those three factors are necessary for the formation of cholesterol gallstones, and the presence of just one or two factors does not lead to stones. We also touch briefly on the results from studies performed in Mexico in this area.
本文的目的是回顾目前关于胆固醇结石病的知识。一般认为，胆固醇结石的形成需要三个主要的致病缺陷，即过饱和、成核和晶体生长以及胆囊运动障碍。过饱和是必要的，但不足以解释结石的形成。有人提出成核是结石形成的关键因素。然而，这三个因素对于胆固醇结石的形成都是必要的，仅存在一两个因素不会导致结石形成。我们还简要介绍了在墨西哥进行的该领域研究的结果。
