Koshida K, Hisazumi H, Komatsu K, Hirata A, Uchibayashi T
Department of Urology, School of Medicine, Kanazawa University, Japan.
Urol Res. 1993;21(4):283-8. doi: 10.1007/BF00307712.
The potency of aluminum-chloro-tetrasulfonated phthalocyanine (AlS4Pc) as a photosensitizer in photodynamic therapy was evaluated in in vitro and in vivo studies. Compared with hematoporphyrin derivative (HpD), the following advantages of AlS4Pc were revealed: (1) AlS4Pc was less toxic than HpD in vitro without light irradiation. (2) AlS4Pc showed more photodynamic-dependent cytotoxicity and anti-tumor effect in the red area of the spectrum (> 660 nm) at which tissue penetration is high. (3) AlS4Pc appeared to be removed more rapidly from normal tissues such as muscle and skin. (4) AlS4Pc showed less photodynamic-dependent cytotoxicity in vitro and milder cutaneous phototoxicity in vivo with UVA irradiation. On the basis of these observations, AlS4Pc shows considerable promise as a photosensitizer for PDT.
通过体外和体内研究评估了四磺化铝酞菁（AlS4Pc）作为光动力疗法中光敏剂的效力。与血卟啉衍生物（HpD）相比，AlS4Pc具有以下优势：（1）在无光照的体外实验中，AlS4Pc的毒性低于HpD。（2）在组织穿透性高的光谱红色区域（>660nm），AlS4Pc表现出更强的光动力依赖性细胞毒性和抗肿瘤作用。（3）AlS4Pc似乎能更快地从肌肉和皮肤等正常组织中清除。（4）在体外实验中，AlS4Pc表现出较低的光动力依赖性细胞毒性，在体内经紫外线A（UVA）照射后表现出较轻的皮肤光毒性。基于这些观察结果，AlS4Pc作为光动力疗法的光敏剂具有很大的前景。
