Tan L, Xu D K, Diao Y, Yuan Y S
Department of Instrumental Analysis, Nanjing General Hospital of Nanjing Command.
Yao Xue Xue Bao. 1993;28(4):286-9.
A sensitive and simplified high performance liquid chromatographic procedure has been developed for quantification of lomefloxacin in human plasma. The recovery of lomefloxacin was 95 to 102%. The relative standard deviation was 2.1 to 7.8%. The calibration curve was linear in the range from 0.125 micrograms/ml to 5.012 micrograms/ml with r = 0.9998. The detection limit of the method is 25 ng/ml. The plasma drug concentration-time course after medication conformed to a 1-compartment open model with a first order absorption. Mean t1/2 value was 5.5 h.
已开发出一种灵敏且简化的高效液相色谱法，用于定量测定人血浆中的洛美沙星。洛美沙星的回收率为95%至102%。相对标准偏差为2.1%至7.8%。校准曲线在0.125微克/毫升至5.012微克/毫升范围内呈线性，r = 0.9998。该方法的检测限为25纳克/毫升。给药后血浆药物浓度-时间过程符合具有一级吸收的一室开放模型。平均t1/2值为5.5小时。
