Bauer L O
Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030-2103.
Addict Behav. 1993 Jul-Aug;18(4):465-72. doi: 10.1016/0306-4603(93)90064-g.
Smooth-pursuit (SPEM) and saccadic (SEM) eye movements were studied in 11 cocaine-dependent and 4 alcohol-dependent patients after 1, 3, and 12 weeks of verified abstinence. Sixteen non-drug-dependent controls were studied after comparable intervals. SPEM tracking accuracy, estimated by the Ln (S/N) statistic, was higher among cocaine-dependent patients than among alcohol-dependent patients and normal controls. A microanalysis of SPEM tracking revealed that the superior accuracy of the cocaine-dependent group was due to a small increase in eye movements at the target frequency (0.4 Hz) and a small compensatory decrease in higher frequency eye movements (i.e., saccades). In contrast to the findings of the SPEM study, the findings of the SEM study revealed that alcohol-dependent patients constituted the only abnormal group. Alcohol-dependent patients exhibited slower saccade onset latencies than the other groups. There were no significant differences among the groups with respect to saccade velocity, amplitude, or duration.
在11名可卡因依赖患者和4名酒精依赖患者经过1周、3周和12周经证实的禁欲期后，对其平稳跟踪（SPEM）和扫视（SEM）眼动进行了研究。在间隔相当的时间后，对16名非药物依赖对照者进行了研究。通过Ln（S/N）统计量估计，可卡因依赖患者的SPEM跟踪准确性高于酒精依赖患者和正常对照者。对SPEM跟踪的微观分析显示，可卡因依赖组的较高准确性是由于目标频率（0.4Hz）时眼动略有增加以及较高频率眼动（即扫视）时有小幅代偿性减少。与SPEM研究结果相反，SEM研究结果显示，酒精依赖患者是唯一异常的组。酒精依赖患者的扫视起始潜伏期比其他组慢。各组在扫视速度、幅度或持续时间方面没有显著差异。
