Safe A F, Warren B, Corfield A, McNulty C A, Watson B, Mountford R A, Read A
Bristol Royal Infirmary.
Age Ageing. 1993 Jul;22(4):256-9. doi: 10.1093/ageing/22.4.256.
Fifteen elderly patients with type B gastritis caused by Helicobacter pylori infection were treated with triple therapy consisting of colloidal bismuth subcitrate, amoxycillin and metronidazole. All were followed up every 6 weeks for 3 months. After triple therapy, eradication of the infection was confirmed in 12 patients (85%) by histology and bacteriology. In this group, a significant reduction in IgG antibody levels against H. pylori was detected (p < 0.001). In a control group of 15 patients with type B gastritis who received no antibacterial treatment, the specific IgG antibody titre remained unchanged during 3 months of follow-up. We conclude that this simple and noninvasive serological test would be suitable for follow-up after treatment of H. pylori infection in elderly patients.
15例由幽门螺杆菌感染引起的B型胃炎老年患者接受了由枸橼酸铋钾、阿莫西林和甲硝唑组成的三联疗法治疗。所有患者每6周随访一次，共随访3个月。三联疗法后，通过组织学和细菌学检查确认12例患者（85%）的感染已根除。在该组中，检测到抗幽门螺杆菌的IgG抗体水平显著降低（p<0.001）。在15例未接受抗菌治疗的B型胃炎对照组患者中，特异性IgG抗体滴度在3个月的随访期间保持不变。我们得出结论，这种简单且非侵入性的血清学检测适用于老年患者幽门螺杆菌感染治疗后的随访。
