Fink L, Bauer F, Perry J J
Department of Medicine, Walter Reed Army Medical Center, Washington, DC.
Am J Hematol. 1993 Nov;44(3):196-200. doi: 10.1002/ajh.2830440311.
Polycythemia vera (PCV) and multiple myeloma are both clonal disorders of hematopoietic stem cells. The simultaneous occurrence of these diseases in an individual patient is rare. A case of synchronous PCV and smoldering myeloma is presented and the literature is reviewed. The issues of clinical importance in this unusual case include the mechanisms of anemia in multiple myeloma, the difficulty in using anemia as a parameter on which to base the initiation of therapy for myeloma, and the risks of treatment-induced leukemia and myelodysplasia.
真性红细胞增多症（PCV）和多发性骨髓瘤均为造血干细胞的克隆性疾病。这两种疾病在单个患者中同时发生的情况较为罕见。本文报告了一例同步发生的真性红细胞增多症和冒烟型骨髓瘤病例，并对相关文献进行了综述。这一罕见病例中具有临床重要性的问题包括多发性骨髓瘤中贫血的机制、将贫血作为启动骨髓瘤治疗的参数存在的困难，以及治疗诱导的白血病和骨髓发育异常的风险。
