Ripa S, Prenna M
Ann Sclavo. 1975;17(5):749-65.
The effectiveness of the combination of carbenicilline and cephaloridine in the ratio of 4:1 was studied. The antibacterial activity of the association whether in vitro or in vivo is sinergic, that is, superior to the simply addition by the individual components. The hematic levels of the combination remain high up to 5 hours after the administration and are greater than those obtained with carbenicilline alone. Levels in the urine are high, therefore the species judged to be resistent in vitro may become sensitive.
研究了羧苄青霉素和头孢菌素按4:1比例联合使用的效果。该联合用药无论是在体外还是体内的抗菌活性都是协同的，也就是说，优于单独使用各组分的简单相加。联合用药后的血药浓度在给药后5小时内仍保持较高水平，且高于单独使用羧苄青霉素时的血药浓度。尿药浓度也很高，因此在体外被判定为耐药的菌株可能会变得敏感。
