Morgan M J, Cascella N G, Stapleton J M, Phillips R L, Yung B C, Wong D F, Shaya E K, London E D
Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.
Am J Psychiatry. 1993 Nov;150(11):1712-7. doi: 10.1176/ajp.150.11.1712.
The purpose of this study was to assess the functional significance of ventricle-brain ratio (VBR) in terms of how it might affect sensitivity to cocaine, an indirect dopamine agonist.
Relationships between VBR and subjective responses to acute intravenous cocaine hydrochloride were examined in 20 male polydrug abusers. Tests were performed in conjunction with positron emission tomography scans to measure cerebral glucose metabolism.
Subjective measures of effects of cocaine, including self-report ratings of intensity of the drug effect, scores on the morphine-benzedrine scale of the Addiction Research Center Inventory, and several items on visual analogue scales, correlated negatively with VBR. VBR also differed significantly among subjects who were grouped according to scores on items ("rush" and "crash") of the Cocaine-Sensitive Scale (larger VBR in subjects with weaker responses). VBR was not correlated with cocaine-induced changes in cerebral metabolic rates for glucose.
Relative insensitivity to the subjective effects of cocaine in polydrug abusers with ventricle enlargement suggests that ventriculomegaly may reflect changes in periventricular brain regions that mediate these effects of cocaine.
本研究的目的是评估脑室脑比率（VBR）在其可能如何影响对可卡因（一种间接多巴胺激动剂）敏感性方面的功能意义。
在20名男性多药滥用者中研究了VBR与急性静脉注射盐酸可卡因主观反应之间的关系。测试与正电子发射断层扫描相结合进行，以测量脑葡萄糖代谢。
可卡因作用的主观指标，包括药物效应强度的自我报告评分、成瘾研究中心量表中吗啡-苯丙胺量表的得分以及视觉模拟量表上的几个项目，与VBR呈负相关。根据可卡因敏感量表项目（“冲动”和“崩溃”）得分分组的受试者中，VBR也存在显著差异（反应较弱的受试者VBR较大）。VBR与可卡因引起的脑葡萄糖代谢率变化无关。
脑室扩大的多药滥用者对可卡因主观效应的相对不敏感表明，脑室扩大可能反映了介导可卡因这些效应的脑室周围脑区的变化。
