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洛伐他汀逆转蓝趾综合征坏疽性病变——一例报告

Reversal of gangrenous lesions in the blue toe syndrome with lovastatin--a case report.

作者信息

Cabili S, Hochman I, Goor Y

机构信息

6th Department of Internal Medicine, Ichilov Hospital, Tel Aviv Medical Centre, Israel.

出版信息

Angiology. 1993 Oct;44(10):821-5. doi: 10.1177/000331979304401010.

DOI:10.1177/000331979304401010
PMID:8214780
Abstract

A seventy-six-year-old man with ischemic heart disease, peripheral vascular disease, and chronic renal failure developed bilateral cyanotic toes, which upon muscle biopsy, were shown to be caused by atheromatous emboli. The probable source was atheromatosis of the abdominal aorta. The toes became gangrenous, but surgical therapy was deferred because the patient was considered a high risk. With lovastatin therapy there was complete healing and except for transient cyanosis related to temporary cessation of therapy, there has been no recurrence for the past thirty months. The possible role of lovastatin in the conservative treatment of this disorder is discussed.

摘要

一名患有缺血性心脏病、外周血管疾病和慢性肾功能衰竭的76岁男性出现双侧脚趾发绀,肌肉活检显示这是由动脉粥样硬化栓子引起的。可能的来源是腹主动脉粥样硬化。脚趾发生坏疽,但由于患者被认为是高危患者,手术治疗被推迟。使用洛伐他汀治疗后完全愈合,除了与暂时停药相关的短暂发绀外,在过去30个月里没有复发。本文讨论了洛伐他汀在这种疾病保守治疗中的可能作用。

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引用本文的文献

1
Atheroembolism.动脉粥样硬化栓塞
Curr Treat Options Cardiovasc Med. 2002 Jun;4(3):255-265. doi: 10.1007/s11936-002-0006-4.
2
Cholesterol emboli syndrome--uncommon or unrecognized?胆固醇栓塞综合征——罕见还是未被认识?
J R Soc Med. 1997 Oct;90(10):543-6. doi: 10.1177/014107689709001005.
3
Cholesterol embolisation after thrombolytic therapy.溶栓治疗后的胆固醇栓塞
Drug Saf. 1996 Feb;14(2):78-84. doi: 10.2165/00002018-199614020-00002.