瘤胃微生物对N端修饰肽和异肽的分解代谢
Breakdown of N-terminally modified peptides and an isopeptide by rumen microorganisms.
作者信息
Wallace R J, Frumholtz P P, Walker N D
机构信息
Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom.
出版信息
Appl Environ Microbiol. 1993 Sep;59(9):3147-9. doi: 10.1128/aem.59.9.3147-3149.1993.
Abstract
Treatment of Trypticase peptides with acetic anhydride, succinic anhydride, or maleic anhydride inhibited their breakdown to ammonia by rumen microorganisms by an average of 89% after 12 h of incubation in vitro. All three treatments gave similar protection. Acetylation also protected dipeptides containing lysine and methionine from degradation. However, more effective protection was obtained by linking lysine and methionine as N-epsilon-methionyl lysine.
摘要
用乙酸酐、琥珀酸酐或马来酸酐处理胰蛋白酶肽，在体外培养12小时后，瘤胃微生物将其分解为氨的过程平均受到89%的抑制。三种处理提供的保护作用相似。乙酰化还保护含赖氨酸和蛋氨酸的二肽不被降解。然而，通过将赖氨酸和蛋氨酸连接成N-ε-甲硫氨酰赖氨酸可获得更有效的保护。
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