青少年皮肌炎患者血清新蝶呤浓度与疾病活动度的相关性
Correlation of serum neopterin concentrations with disease activity in juvenile dermatomyositis.
作者信息
De Benedetti F, De Amici M, Aramini L, Ruperto N, Martini A
机构信息
Clinica Pediatrica, IRCCS Policlinico San Matteo, Università di Pavia, Italy.
出版信息
Arch Dis Child. 1993 Aug;69(2):232-5. doi: 10.1136/adc.69.2.232.
Serum neopterin concentrations were measured in 15 patients with juvenile dermatomyositis and their correlation with the severity of muscle impairment was evaluated. Neopterin concentrations were measured by radioimmunoassay. When compared with controls (median 0.75 ng/ml; range 0.33-1.18), serum neopterin concentrations were increased in patients with active juvenile dermatomyositis (median 3.21 ng/ml; range 0.95-13.81), but not in patients during remission (median 0.81 ng/ml; range 0.55-1.34). In horizontal and longitudinal studies, serum neopterin was significantly correlated with the severity of muscle strength impairment, whereas serum muscle enzyme values were not. These data suggest that measurement of serum neopterin may be used, together with clinical examination, to guide the treatment of patients with juvenile dermatomyositis.
检测了15例青少年皮肌炎患者的血清新蝶呤浓度，并评估了其与肌肉损伤严重程度的相关性。采用放射免疫分析法测定新蝶呤浓度。与对照组（中位数0.75 ng/ml；范围0.33 - 1.18）相比，活动期青少年皮肌炎患者的血清新蝶呤浓度升高（中位数3.21 ng/ml；范围0.95 - 13.81），而缓解期患者则未升高（中位数0.81 ng/ml；范围0.55 - 1.34）。在横向和纵向研究中，血清新蝶呤与肌肉力量损伤的严重程度显著相关，而血清肌肉酶值则不然。这些数据表明，血清新蝶呤的检测可与临床检查一起用于指导青少年皮肌炎患者的治疗。
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