Thisted E, Ebbesen F
Department of Paediatrics, Aalborg Hospital, Denmark.
Arch Dis Child. 1993 Sep;69(3 Spec No):288-91. doi: 10.1136/adc.69.3_spec_no.288.
An unselected series is presented of 17 infants born to epileptic mothers and exposed to sodium valproate during pregnancy. Nine infants had minor abnormalities and of these infants five also had major malformations, described as the 'fetal valproate syndrome'. The most frequent malformation was congenital heart disease. Nine of the infants had manifestations of withdrawal, such as irritability, jitteriness, abnormalities of tone, seizures, and feeding problems. Four of these infants had an unrelated hypoglycaemia. The frequency of withdrawal symptoms was significantly related to the dose of valproate given to the mothers in the third trimester, and there was a tendency for both the frequency of the minor abnormalities and the major malformations to be related to the valproate dosage in the first trimester.
本文报告了一组未经选择的病例，17名癫痫母亲所生婴儿在孕期接触丙戊酸钠。9名婴儿有轻微异常，其中5名还有严重畸形，被称为“胎儿丙戊酸盐综合征”。最常见的畸形是先天性心脏病。9名婴儿有戒断表现，如易激惹、震颤、肌张力异常、惊厥和喂养问题。其中4名婴儿有不相关的低血糖。戒断症状的发生率与孕晚期母亲服用丙戊酸盐的剂量显著相关，轻微异常和严重畸形的发生率有与孕早期丙戊酸盐剂量相关的趋势。
