Fuse H, Ohta S, Sakamoto M, Katayama T
Department of Urology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Arch Androl. 1993 Sep-Oct;31(2):139-45. doi: 10.3109/01485019308988392.
This study was designed to investigate the functional changes in Sertoli cells following clomiphene citrate administration to patients with idiopathic infertility. The agent was administered to 44 oligozoospermic patients. Patients with improvement in sperm concentration after treatment (improvement group) showed significantly lower pretreatment follicle-stimulating hormone (FSH) levels in serum. Serum FSH and testosterone levels significantly increased in the improvement group after treatment (both p < 0.05). Seminal transferrin concentration significantly increased in the improvement group after treatment (p < 0.05), although there was no significant difference between pretreatment seminal transferrin concentration in the improvement group and that in patients with no improvement in sperm concentration. Seminal plasma transferrin concentration in patients in whom pretreatment luteinizing hormone level in serum was below 10 mIU/mL, and in those in whom the ratio of post- to pretreatment values was 1.5 or more, tended to increase after treatment. This group also contained a few more patients with improvement in sperm concentration than the other groups. The patients showing low pretreatment FSH levels and a high ratio of post- to pretreatment values demonstrated a significant increase in seminal plasma transferrin concentration after treatment (p < 0.01), and this group contained more patients with improvement than the other groups. It would appear that Sertoli cell stimulation may induce an increase in sperm concentration after clomiphene citrate administration, and the elevated transferrin secretion seems to be associated with the increase of serum FSH level after treatment.
本研究旨在调查枸橼酸氯米芬治疗特发性不育患者后支持细胞的功能变化。该药物应用于44例少精子症患者。治疗后精子浓度有所改善的患者（改善组）血清中治疗前促卵泡激素（FSH）水平显著较低。治疗后改善组血清FSH和睾酮水平显著升高（均p<0.05）。治疗后改善组精浆转铁蛋白浓度显著升高（p<0.05），尽管改善组治疗前精浆转铁蛋白浓度与精子浓度无改善患者的治疗前精浆转铁蛋白浓度之间无显著差异。血清促黄体生成素水平治疗前低于10 mIU/mL以及治疗后与治疗前比值为1.5或更高的患者，其精浆转铁蛋白浓度治疗后有升高趋势。该组精子浓度改善的患者也比其他组略多。治疗前FSH水平较低且治疗后与治疗前比值较高的患者，治疗后精浆转铁蛋白浓度显著升高（p<0.01），且该组改善患者比其他组更多。枸橼酸氯米芬治疗后支持细胞的刺激似乎可诱导精子浓度增加，转铁蛋白分泌升高似乎与治疗后血清FSH水平升高有关。
