Chopra K, Singh M, Kaul N, Ganguly N K
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Arch Int Pharmacodyn Ther. 1993 Mar-Apr;322:55-65.
Captopril (0.25 mg/kg and 0.5 mg/kg, p.o.) decreased the myocardial infarct size and prevented the progressive decrease in voltage of the R wave in rats. It had no marked effect on systolic blood pressure at these dose levels but higher doses (1 mg/kg, p.o.) reduced systolic blood pressure. It also produced a concentration-dependent (50-700 ng/10(6) cells) decrease of chemiluminescence response from rat neutrophils and markedly reduced serum malonyldialdehyde levels, elevated as a consequence of left coronary artery ligation. It is suggested that the protective effect of captopril may be mediated through a decreased formation or scavenging of reactive oxygen species.
卡托普利（0.25毫克/千克和0.5毫克/千克，口服）可减小大鼠心肌梗死面积，并防止R波电压的逐渐降低。在这些剂量水平下，它对收缩压没有显著影响，但更高剂量（1毫克/千克，口服）可降低收缩压。它还使大鼠中性粒细胞的化学发光反应呈浓度依赖性（50 - 700纳克/10⁶细胞）降低，并显著降低血清丙二醛水平，后者因左冠状动脉结扎而升高。提示卡托普利的保护作用可能通过减少活性氧的生成或清除来介导。
