Ranaut K, Singh M
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Methods Find Exp Clin Pharmacol. 1993 Jan-Feb;15(1):9-14.
Anesthetized rats were subjected to coronary artery ligation (CAL) for 72 h and infarct size was measured macroscopically using TTC staining. Systolic blood pressure and ECG were monitored. BN-50739 (5 mg/kg i.p.) decreased the myocardial infarct size in rats. It prevented the loss of R wave, an electrophysiological measure of ischemic injury in this model. In addition, BN-50739 markedly reduced serum malondialdehyde levels elevated as a consequence of CAL. It is speculated that being a PAF antagonist, BN-50739 decreased lipid peroxidation, perhaps by inhibiting migration of PMN cells to the site of ischemic injury through the limited collateral flow available in rat myocardium, and consequently may have reduced the generation of oxygen reactive species. This may be responsible for its beneficial effect in limiting infarct size.
将麻醉的大鼠进行冠状动脉结扎（CAL）72小时，并用TTC染色宏观测量梗死面积。监测收缩压和心电图。BN - 50739（5毫克/千克腹腔注射）可减小大鼠心肌梗死面积。它防止了R波丢失，R波丢失是该模型中缺血性损伤的一种电生理指标。此外，BN - 50739显著降低了因CAL而升高的血清丙二醛水平。据推测，作为一种血小板活化因子（PAF）拮抗剂，BN - 50739可减少脂质过氧化，可能是通过抑制中性粒细胞（PMN）通过大鼠心肌中有限的侧支血流迁移至缺血损伤部位，从而可能减少了氧活性物质的生成。这可能是其在限制梗死面积方面产生有益作用的原因。
