Lacour M, Roll J P, Appaix M
Brain Res. 1976 Aug 27;113(2):255-69. doi: 10.1016/0006-8993(76)90940-9.
Unilateral vestibular neurotomy performed on 6 baboons was followed by the classical postural and locomotor postoperative disorders. Postoperative spinal reflex excitability was studied in these awake baboons by measuring monosynaptic recruitment ratios in soleus motoneuronal pool and the recovery cycle of the monosynaptic response. Vestibular neurotomy induces: (1) asymmetrical spinal reflexes with a decrease of the recruitment on the side of the section and an increase on the opposite side. (2) a modification of phases IV and V of the ipsilateral recovery cycle. The recovery during postoperative days of normal recruitment curves and recovery cycles is described. This recovery is relatively fast and relates closely to the compensation of postural and locomotor disorders. We note the importance of an early active motor exploration on the time-course of recovery: postoperative disorders in posture and locomotion are reduced much later when baboons are submitted to a motor restriction. These findings suggest a combined alpha and gamma-hypoexcitability of the ipsilateral hindlimb. The study of the recovery process suggests that the cerebellum is involved in the compensatory mechanisms. The regression of postural disorders, observed both in restrained and unrestrained baboons, demonstrates the importance of central regulations using proprioceptive afferents for recovery.
对6只狒狒进行单侧前庭神经切断术后，出现了典型的术后姿势和运动障碍。通过测量比目鱼肌运动神经元池中的单突触募集比率和单突触反应的恢复周期，对这些清醒的狒狒术后脊髓反射兴奋性进行了研究。前庭神经切断术会引发：（1）脊髓反射不对称，切断侧的募集减少，对侧增加。（2）同侧恢复周期的IV期和V期发生改变。描述了术后正常募集曲线和恢复周期的恢复情况。这种恢复相对较快，且与姿势和运动障碍的代偿密切相关。我们注意到早期主动运动探索对恢复进程的重要性：当狒狒受到运动限制时，姿势和运动的术后障碍在很久之后才会减轻。这些发现表明同侧后肢存在α和γ联合低兴奋性。对恢复过程的研究表明小脑参与了代偿机制。在受约束和不受约束的狒狒中均观察到姿势障碍的消退，这表明利用本体感觉传入进行中枢调节对恢复很重要。
