阿尔茨海默病中的血管淀粉样蛋白沉积。对于局部斑块或缠结的形成既非必要条件也非充分条件。
Vascular amyloid deposition in Alzheimer's disease. Neither necessary nor sufficient for the local formation of plaques or tangles.
作者信息
Lippa C F, Hamos J E, Smith T W, Pulaski-Salo D, Drachman D A
机构信息
Department of Neurology, University of Massachusetts Medical Center, Worcester 01655.
出版信息
Arch Neurol. 1993 Oct;50(10):1088-92. doi: 10.1001/archneur.1993.00540100073019.
OBJECTIVE
To determine the relationship between vascular beta-amyloid (beta A4) and senile plaques (SPs) and neurofibrillary tangles (NFTs).
DESIGN
We counted vascular amyloid deposition with SP and NFT density in the medial temporal lobe (CA1 plus the subiculum) and the cerebellum.
PATIENTS
The brains of seven patients with Alzheimer's disease and of three age-matched nondemented control subjects were studied.
RESULTS
In Alzheimer's disease, the density of beta A4-laden blood vessels was significantly higher in the cerebellum than in CA1 plus the subiculum. Conversely, the densities of SPs and NFTs were much greater in the CA1 plus the subiculum than in the cerebellum.
CONCLUSIONS
This study indicates that local vascular beta A4 deposition is not directly correlated with SP and NFT densities. Deposition of beta A4 in blood vessel walls may not be instrumental in the formation of SPs and/or NFTs in the brain.
目的
确定血管β淀粉样蛋白（βA4）与老年斑（SPs）及神经原纤维缠结（NFTs）之间的关系。
设计
我们在内侧颞叶（CA1加上海马下托）和小脑中对血管淀粉样蛋白沉积与SP和NFT密度进行计数。
患者
研究了7例阿尔茨海默病患者及3例年龄匹配的非痴呆对照受试者的大脑。
结果
在阿尔茨海默病中，小脑内载有βA4的血管密度显著高于CA1加上海马下托内的密度。相反，CA1加上海马下托内的SP和NFT密度比小脑中的密度大得多。
结论
本研究表明局部血管βA4沉积与SP和NFT密度无直接相关性。血管壁中βA4的沉积可能对大脑中SP和/或NFT的形成不起作用。
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