Rieber M, Romano E
Cancer Res. 1976 Oct;36(10):3568-73.
Antiserum against antigens released into the medium by rat cell cultures that express the transformation phenotype has been shown to produce a complement-mediated lysis, not only in the cells that liberate such antigens but to a greater extent in cells that are phenotypically restricted in the expression of transformation properties. Reaction of the antibody with preiodinated surface proteins released into the medium reveals that the expression of transformation leads to a greater degradation of the external proteins shed into the medium.
针对由表达转化表型的大鼠细胞培养物释放到培养基中的抗原的抗血清，已显示不仅能在释放此类抗原的细胞中产生补体介导的裂解，而且在转化特性表达受到表型限制的细胞中产生的裂解作用更强。抗体与释放到培养基中的碘化前表面蛋白的反应表明，转化的表达导致释放到培养基中的外部蛋白有更大程度的降解。
