Serrat-Serrat J, Ordóñez-Llanos J, Serra-Grima R, Gómez-Gerique J A, Pellicer-Thoma E, Payés-Romero A, González-Sastre F
Departament de Bioquímica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Atherosclerosis. 1993 Jun;101(1):43-9. doi: 10.1016/0021-9150(93)90100-9.
Acute exercise promotes raised HDL cholesterol concentrations by lipolysis stimulation, but this effect is insufficient to explain the more permanent HDL increases seen during regular exercise. During training periods in a group of marathon runners, we measured lipid transfer protein I (LTP-I)-mediated cholesteryl ester transfer activity (CETA) and its relationship to their HDL concentrations. Runners of both sexes showed significantly lower CETA values than those of sedentary controls. Male runners also had significantly lower serum concentrations of triglyceride, VLDL cholesterol and apolipoprotein B, and significantly higher concentrations of HDL cholesterol and apolipoprotein A-I than male controls. Results indicate that regular practice of aerobic exercise promotes modifications of lipoprotein metabolism related not only to lipolysis, but also to lower CETA. Such modifications are associated with reduced risk of atherosclerosis.
急性运动通过刺激脂肪分解来提高高密度脂蛋白胆固醇（HDL-C）浓度，但这种效应不足以解释规律运动期间HDL更持久的升高。在一组马拉松运动员的训练期间，我们测量了脂质转运蛋白I（LTP-I）介导的胆固醇酯转运活性（CETA）及其与HDL浓度的关系。男女跑步者的CETA值均显著低于久坐不动的对照组。男性跑步者的血清甘油三酯、极低密度脂蛋白胆固醇和载脂蛋白B浓度也显著低于男性对照组，而HDL胆固醇和载脂蛋白A-I浓度则显著高于男性对照组。结果表明，规律进行有氧运动不仅促进了与脂肪分解相关的脂蛋白代谢改变，还降低了CETA。这些改变与动脉粥样硬化风险降低有关。
