Offermann G, Schwarz A, Krause P H
Klinikum Steglitz, Freie Universität Berlin, Germany.
Transpl Int. 1993;6(5):290-2. doi: 10.1007/BF00336030.
The long-term graft function after withdrawal of steroids from maintenance immunosuppression was analyzed in 98 kidney recipients (59 on cyclosporin monotherapy, 39 on cyclosporin plus azathioprine) who had not developed an early rejection episode when prednisolone was discontinued. Seven years after steroid withdrawal the probability of an increase in serum creatinine (> 20% of baseline levels) was 51%. The increase in creatinine was associated with sclerosing arteriopathy as a marker of chronic rejection in 29 of 43 graft biopsies. The addition of azathioprine had no effect on the stability of long-term graft function and did not influence the 7-year graft survival rate in this highly selected group of patients.
对98例肾移植受者（59例接受环孢素单一疗法，39例接受环孢素加硫唑嘌呤治疗）进行了分析，这些患者在停用泼尼松龙时未发生早期排斥反应，研究了维持免疫抑制治疗中停用类固醇后的长期移植肾功能。停用类固醇7年后，血清肌酐升高（>基线水平的20%）的概率为51%。在43例移植肾活检中，有29例肌酐升高与作为慢性排斥反应标志物的硬化性动脉病有关。在这一经过高度筛选的患者组中，添加硫唑嘌呤对长期移植肾功能的稳定性没有影响，也不影响7年移植肾存活率。
