Hornebeck W, Derouette J C, Roland J, Châtelet F, Bouissou H, Robert L
C R Acad Hebd Seances Acad Sci D. 1976 Jun 14;282(22):2003-6.
An elastolytic protease was isolated recently from human and animal aortic wall. We report here the positive correlation between the activity of human aortic elastase, the degree of atherosclerosis and age. These two parameters appear to influence independently and in an additive fashion the level of aortic elastase. There appears to be an increasing synthesis and/or liberation of aortic elastase with age. This process is accelerated in the presence of arteriosclerosis. It appears probable that the increasing elastolytic activity is mainly responsible for the fregmentation and lysis of the elastic fibers with age and arteriosclerosis as observed with histochemical techniques.
最近从人和动物的主动脉壁中分离出一种弹性蛋白酶。我们在此报告人主动脉弹性蛋白酶的活性、动脉粥样硬化程度和年龄之间的正相关关系。这两个参数似乎以独立且累加的方式影响主动脉弹性蛋白酶的水平。随着年龄的增长，主动脉弹性蛋白酶的合成和/或释放似乎在增加。在存在动脉硬化的情况下，这个过程会加速。随着年龄增长和动脉硬化，弹性纤维的碎片化和溶解如通过组织化学技术所观察到的那样，似乎很可能主要是由不断增加的弹性蛋白酶活性所导致的。
