Bray G A, Greenway F L
Clin Endocrinol Metab. 1976 Jul;5(2):455-79. doi: 10.1016/s0300-595x(76)80031-x.
It should be obvious from the foregoing discussion that, at the present time, there is not an acceptably safe and effective pharmacological treatment for obesity. This patent inadequacy of present drug regimens has spawned the investigation into the diverse pharmacological approaches reviewed in this paper as well as investigation into the intestinal bypass operation (see Chapter 10). We feel that the eventual, safe and effective therapy for obesity will come from the pharmacological realm. Glucose-blocking drugs, growth hormone analogues, and hydroxycitrate are but three of the potentially safe and effective approaches to the problem for the future. It will be truly fascinating to watch the development in the treatment of obesity and, specifically, the pharmacological treatment for this problem over the next five to ten years.
从上述讨论中应该可以明显看出,目前尚无一种可接受的安全有效的肥胖症药物治疗方法。当前药物治疗方案的这种明显不足引发了对本文所综述的各种药理学方法的研究,以及对肠道分流手术的研究(见第10章)。我们认为,肥胖症最终的安全有效治疗方法将来自药理学领域。葡萄糖阻断药物、生长激素类似物和羟基柠檬酸只是未来解决该问题的三种潜在安全有效的方法。观察未来五到十年肥胖症治疗的发展,尤其是针对这个问题的药物治疗,将会非常有趣。