肥胖症的药物治疗

Pharmacological treatment of obesity.

作者信息

Sullivan A C, Comai K

出版信息

Int J Obes. 1978;2(2):167-89.

Abstract

Obesity results when the ingestion of energy exceeds its utilization, leading to an excessive expansion of the adipose tissue mass. Current pharmacological therapy for the obese patient focuses primarily on reducing energy intake. Anorectic agents reduce food consumption by modifying central systems in the brain which are involved in appetite regulation. These agents are reviewed in terms of mechanism of action, and clinical safety and efficacy in suppressing appetite and promoting weight loss. Newer anorectic agents which are being evaluated currently in clinical and animal studies are described. Clinical assessments of therapeutic regimens utilizing the thyroid hormones and human chorionic gonadotropin are evaluated. Finally, an overview of novel pharmacological approaches to the treatment of obesity is presented.

摘要

当能量摄入超过其消耗时，就会导致肥胖，进而使脂肪组织大量过度扩张。目前针对肥胖患者的药物治疗主要集中在减少能量摄入上。食欲抑制剂通过改变大脑中参与食欲调节的中枢系统来减少食物消耗。本文将从作用机制、临床安全性以及抑制食欲和促进减肥的疗效等方面对这些药物进行综述。还将介绍目前正在临床和动物研究中评估的新型食欲抑制剂。对使用甲状腺激素和人绒毛膜促性腺激素的治疗方案进行临床评估。最后，概述治疗肥胖的新型药理学方法。