Kostowski W, Dyr W, Krzaścik P
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
Alcohol. 1993 Sep-Oct;10(5):369-73. doi: 10.1016/0741-8329(93)90022-g.
Recent evidence suggests that central 5-HT3 are intimately involved in the ethanol (ETOH) dependence mechanism. In the present study we observed the effects of the 5-HT3 receptor antagonist ICS 205-930 on audiogenic seizure response (ASR) in ETOH-withdrawn rats and on ETOH intake and preference. Low doses of ICS 205-930 (0.001 mg/kg), but not higher doses (0.1 mg/kg), markedly reduced both ASR and ETOH intake in a high preference group of animals. The possible mechanism of different effects of low and high drug doses is discussed.
最近的证据表明，中枢5-羟色胺3（5-HT3）与乙醇（ETOH）依赖机制密切相关。在本研究中，我们观察了5-HT3受体拮抗剂ICS 205-930对乙醇戒断大鼠听源性惊厥反应（ASR）以及乙醇摄入量和偏好的影响。低剂量的ICS 205-930（0.001毫克/千克），而非高剂量（0.1毫克/千克），能显著降低高偏好组动物的ASR和乙醇摄入量。文中讨论了药物高低剂量产生不同效应的可能机制。
