Halvorson M R, Noffsinger J K, Peterson C M
Home Office Reference Laboratory, Shawnee Mission, KS 66201.
Alcohol. 1993 Sep-Oct;10(5):409-13. doi: 10.1016/0741-8329(93)90029-n.
We measured whole blood-associated acetaldehyde (WBAA) levels in 225 teetotalers (123 females, 102 males) between the ages of 18 and 86 years. Values were normally distributed, but mean values for females were significantly lower than for males (7.6 +/- 0.6 vs. 7.9 +/- 0.7 microM, p < 0.0001). There was a significant positive correlation with age for the entire group (r2 = 0.149, p = 0.001) and for both sexes. The correlation with WBAA and age was stronger for females. Significant but lesser positive correlations were found between WBAA and other variables that increase with age, including glucose, fructosamine, cholesterol, alkaline phosphatase, serum glutamate pyruvate transaminase (SGPT), gamma glutamyl transpeptidase (GGT), and creatinine in the entire data set. Partial r analyses indicated that the correlations were mediated through the primary association of WBAA and age. We conclude that in individuals who do not consume ethanol there are significant sex differences in whole blood acetaldehyde and that the values increase throughout life.
我们测量了225名年龄在18至86岁之间的戒酒者（123名女性，102名男性）全血相关乙醛（WBAA）水平。数值呈正态分布，但女性的平均值显著低于男性（7.6±0.6对7.9±0.7微摩尔，p<0.0001）。整个组以及男女两性中，WBAA与年龄均呈显著正相关（r2 = 0.149，p = 0.001）。女性中WBAA与年龄的相关性更强。在整个数据集中，还发现WBAA与其他随年龄增加的变量之间存在显著但较弱的正相关，包括葡萄糖、果糖胺、胆固醇、碱性磷酸酶、血清谷丙转氨酶（SGPT）、γ-谷氨酰转肽酶（GGT）和肌酐。偏相关分析表明，这些相关性是通过WBAA与年龄的主要关联介导的。我们得出结论，在不摄入乙醇的个体中，全血乙醛存在显著的性别差异，且其数值终生增加。
