Reynolds G P, Stroud D
Department of Biomedical Science, University of Sheffield, United Kingdom.
J Neural Transm Gen Sect. 1993;93(2):151-5. doi: 10.1007/BF01245344.
Benzodiazepine receptor sites were determined by saturable [3H]flunitrazepam binding in hippocampal tissue from schizophrenic and control subjects. No difference in receptor density or affinity between the two groups was observed, indicating that the previously identified GABAergic deficit in the hippocampus in schizophrenia does not apparently lead to up-regulation of these receptor sites. The implications of this finding are discussed.
通过在精神分裂症患者和对照受试者的海马组织中进行饱和[³H]氟硝西泮结合来确定苯二氮卓受体位点。两组之间未观察到受体密度或亲和力的差异，这表明先前确定的精神分裂症患者海马中γ-氨基丁酸能缺陷显然不会导致这些受体位点的上调。本文讨论了这一发现的意义。
