Cross A J, Crow T J, Johnson J A, Perry E K, Perry R H, Blessed G, Tomlinson B E
J Neurol Sci. 1984 May;64(2):109-17. doi: 10.1016/0022-510x(84)90029-7.
Ligand binding to alpha 1-, alpha 2- and beta-adrenergic, serotonin, benzodiazepine and GABA receptors was studied in neocortex and hippocampus of controls and patients with senile dementia of the Alzheimer-type. A selective loss of serotonergic binding sites characterised as a loss of both S1 and S2 sites was observed. The reduction in serotonin receptors did not correlate with a clinical assessment of the degree of dementia, or with the extent of Alzheimer-type neuropathological change.
在对照组以及阿尔茨海默型老年痴呆症患者的新皮层和海马体中，研究了配体与α1、α2和β肾上腺素能、5-羟色胺、苯二氮䓬和GABA受体的结合情况。观察到5-羟色胺能结合位点的选择性丧失，其特征为S1和S2位点均丧失。5-羟色胺受体的减少与痴呆程度的临床评估或阿尔茨海默型神经病理变化的程度均无关联。
