Ljungman P
Huddinge University, Sweden.
Ann Med. 1993 Aug;25(4):329-33. doi: 10.3109/07853899309147293.
Herpes virus infections are responsible for morbidity and mortality among immunosuppressed patients. During the last decade substantial advances have been achieved through improvement of diagnostic techniques, development of effective antiviral agents and the use of different strategies for prophylaxis and treatment. Cytomegalovirus infection and disease can today be prevented and treated effectively; however, antiviral resistance is beginning to emerge as a potential major clinical problem. Similarly, infections with herpes simplex virus and varicella-zoster virus can be effectively treated, but antiviral resistance has also emerged for these viruses. Two new herpes viruses, human herpes viruses 6 and 7, have been discovered, and it is possible that these viruses can also cause significant problems in immunosuppressed individuals. New antiviral agents will be needed during the next decade to allow further advances in the treatment of herpes virus infections.
疱疹病毒感染是免疫抑制患者发病和死亡的原因。在过去十年中，通过改进诊断技术、开发有效的抗病毒药物以及采用不同的预防和治疗策略，已取得了重大进展。如今，巨细胞病毒感染和疾病能够得到有效预防和治疗；然而，抗病毒耐药性正开始成为一个潜在的主要临床问题。同样，单纯疱疹病毒和水痘 - 带状疱疹病毒感染也能得到有效治疗，但这些病毒也出现了抗病毒耐药性。两种新的疱疹病毒，即人类疱疹病毒6型和7型已被发现，并且这些病毒也有可能在免疫抑制个体中引发重大问题。未来十年将需要新的抗病毒药物，以使疱疹病毒感染的治疗取得进一步进展。
