Oursler M J, Landers J P, Riggs B L, Spelsberg T C
Department of Biochemistry and Molecular Biology, Mayo Foundation, Mayo Clinic, Rochester, MN 55905.
Ann Med. 1993 Aug;25(4):361-71. doi: 10.3109/07853899309147298.
Although it has been recognized for many years that oestrogen is a key component in the maintenance of normal bone balance, the mechanisms by which oestrogen exerts its influence have remained unresolved. Recent identification of oestrogen receptors in both bone-forming osteoblasts and bone-resorbing osteoclasts has opened up exciting new areas of research on the direct effects of oestrogen on both osteoblasts and osteoclasts. This review presents an updated model for the molecular mechanisms involved in oestrogen action, the mechanism of anti-oestrogen action, and outlines recent advances in knowledge of oestrogen effects on osteoblasts, osteoclasts, and the coupling of bone resorption and bone formation.
尽管多年来人们已经认识到雌激素是维持正常骨平衡的关键成分，但其发挥作用的机制仍未得到解决。最近在成骨的成骨细胞和骨吸收的破骨细胞中均发现了雌激素受体，这为雌激素对成骨细胞和破骨细胞的直接作用开辟了令人兴奋的新研究领域。本文综述了雌激素作用相关分子机制、抗雌激素作用机制的最新模型，并概述了雌激素对成骨细胞、破骨细胞以及骨吸收与骨形成偶联作用的最新研究进展。
