Kaasa S, Kragh-Jensen E, Bjordal K, Lund E, Evensen J F, Vermund H, Monge O, Boehler P
Department of Medical Oncology and Radiotherapy, Norwegian Radium Hospital, Oslo.
Acta Oncol. 1993;32(5):531-6. doi: 10.3109/02841869309096113.
From 1971 to 1985 a total of 122 patients with non-distant metastatic nasopharyngeal carcinoma were treated at the Norwegian Radium Hospital with radiation doses that increased from 50 Gy (at 2 Gy/fractions) to 70 Gy (at 2 Gy/fractions) during the treatment period. Possible relationship between the increase in dose and survival time was investigated. The median cancer-specific survival time was 50 months, and the median crude survival time 38 months. No correlation was found between radiation dose and survival time. In a multivariate analysis histology was found to be the most important prognostic factor for survival with a relative risk of death from cancer of 3.4 and 3.2 for non-keratinizing carcinoma and squamous cell carcinoma respectively compared with undifferentiated carcinoma. When assessed in terms of N category the relative death risk for N2/N3 was 2.1 compared to N0/N1.
1971年至1985年期间，挪威镭医院共治疗了122例非远处转移性鼻咽癌患者，治疗期间的放射剂量从50 Gy（每次2 Gy分割）增加到70 Gy（每次2 Gy分割）。研究了剂量增加与生存时间之间的可能关系。癌症特异性生存时间中位数为50个月，粗生存时间中位数为38个月。未发现放射剂量与生存时间之间存在相关性。在多变量分析中，组织学被发现是生存的最重要预后因素，与未分化癌相比，非角化癌和鳞状细胞癌的癌症相关死亡相对风险分别为3.4和3.2。按N分期评估时，N2/N3的相对死亡风险为2.1，而N0/N1为1。
