Sumida C, Vallette G, Thobie N, Nunez E A
INSERM U224 affiliated with CNRS, Faculté de Médecine Xavier Bichat, Paris, France.
AIDS Res Hum Retroviruses. 1993 Aug;9(8):755-60. doi: 10.1089/aid.1993.9.755.
Liposoluble extracts of serum from healthy men and AIDS patients (stages IVC1 and IVD by CDC criteria) inhibited the incorporation of [3H]thymidine into isolated rat thymocytes, but AIDS extracts were less inhibitory, requiring 1.8 times more cortisol in the AIDS extracts than in the healthy extracts to inhibit [3H]thymidine incorporation by 50%. Although the total serum extracts from AIDS patients contained 1.7 times more cortisol than the extracts from healthy controls, the AIDS extracts decreased the binding affinity (Ka) of [3H]dexamethasone to rat thymus glucocorticoid receptors by 50% less than the healthy control extracts. The present study seems to indicate that a substance(s) can be extracted from the serum of AIDS patients that attenuates the inhibitory effect of cortisol on thymocyte proliferation and interferes with the binding of cortisol to the glucocorticoid receptor.
健康男性和艾滋病患者（根据美国疾病控制与预防中心标准为IVC1期和IVD期）血清的脂溶性提取物抑制了[3H]胸腺嘧啶核苷掺入分离的大鼠胸腺细胞，但艾滋病患者的提取物抑制作用较弱，艾滋病提取物中抑制[3H]胸腺嘧啶核苷掺入50%所需的皮质醇比健康提取物多1.8倍。尽管艾滋病患者的血清总提取物中皮质醇含量比健康对照者的提取物高1.7倍，但艾滋病提取物使[3H]地塞米松与大鼠胸腺糖皮质激素受体的结合亲和力（Ka）降低的幅度比健康对照提取物少50%。本研究似乎表明，可从艾滋病患者血清中提取出一种物质，该物质可减弱皮质醇对胸腺细胞增殖的抑制作用，并干扰皮质醇与糖皮质激素受体的结合。
