Tanaka S, Kitada T, Kanazawa A, Ueda G, Noguchi K, Mori H, Kondo T, Shirai T, Mizuno Y
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
No To Shinkei. 1993 Aug;45(8):777-87.
We report a 62-year-old man with a pelvic mass, who developed multiple cranial nerve palsies on the right side. He was well until the summer of 1977 when he developed a numb sensation in the sacral region. In the next year, a huge tumor was found in the sacral area in another hospital. Most of the tumor was resected at that time. Post-operative course was uneventful. In July 1988, there was an onset of weakness in his legs, gait disturbance, and dysuria. Myelography at the above hospital revealed a complete block at the seventh thoracic level. He was treated by laminectomy and post-operative radiation. In June 1990, he developed a neuralgic pan in his right leg. Two months later, he noted diplopia, deafness in his right ear, and swallowing difficulty. He was admitted to our hospital for further work up on January 14th of 1991. On admission, he was afebrile. General physical examination revealed a 4 cm had mass in his right anterior chest attaching the rib. Gynecomastia was noted bilaterally. Liver was felt by 5 cms under the right hypochondrium. The edge of the liver was firm. On neurologic examination he was an alert and mentally sound man. His higher cerebral functions were intact. In the cranial nerves, complete palsy of the abducens nerve, mild nerve deafness, paresis of the soft palate, atrophy and weakness of the sternocleidomastoid and upper trapezium muscles, all on the right side, deviation of the tongue to the right, slurred speech, and dysphagia were observed. The neck was supple. He was able to walk with a support. Mild weakness was present in his right lower extremity. Both legs were spastic. No ataxia or involuntary movements were noted. Deep reflexes were symmetric and normally active. No sensory loss was observed. No meningeal signs were present. Pertinent laboratory findings included moderate anemia (Hb 8.8 g/dl), LDH 2,631 U/l, CRP 7.4 mg/dl. The CSF was under an increased pressure (OP 260 mmH2O) containing 2 lymphocytes/ml, 43 mg/dl of protein, and 49 mg/dl of glucose. Radiologic examinations revealed a destructive change in the sacrum, lytic lesions in the seventh thoracic spine and in the clivus.(ABSTRACT TRUNCATED AT 400 WORDS)
我们报告一名62岁男性,患有盆腔肿物,并出现右侧多发颅神经麻痹。他此前身体状况良好,直到1977年夏天骶部出现麻木感。次年,在另一家医院的骶部发现一个巨大肿瘤,当时大部分肿瘤被切除,术后恢复顺利。1988年7月,他开始出现腿部无力、步态障碍和排尿困难。上述医院的脊髓造影显示在胸7水平完全梗阻,他接受了椎板切除术及术后放疗。1990年6月,他出现右腿神经痛。两个月后,他注意到复视、右耳聋和吞咽困难。1991年1月14日因进一步检查入住我院。入院时体温正常。全身检查发现右前胸有一个4厘米大小的肿物附着于肋骨,双侧有男性乳房发育,在右肋弓下5厘米处可触及肝脏,肝脏边缘坚硬。神经系统检查显示他神志清醒、精神状态良好,高级脑功能正常。颅神经方面,右侧展神经完全麻痹、轻度神经性耳聋、软腭麻痹、胸锁乳突肌和上斜方肌萎缩及无力、舌头偏向右侧、言语含糊不清和吞咽困难。颈部柔软,他需借助支撑才能行走,右下肢轻度无力,双腿痉挛,未发现共济失调或不自主运动,深反射对称且正常活跃,未观察到感觉丧失,无脑膜刺激征。相关实验室检查结果包括中度贫血(血红蛋白8.8克/分升)、乳酸脱氢酶2631国际单位/升、C反应蛋白7.4毫克/分升。脑脊液压力升高(压力260毫米水柱),每毫升含2个淋巴细胞、蛋白43毫克/分升、葡萄糖49毫克/分升。影像学检查显示骶骨有破坏性改变,胸7椎体和斜坡有溶骨性病变。(摘要截取自400字)