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一名66岁男性,伴有背痛及进行性步态障碍。

[A 66-year-old man with backache and progressive difficulty of gait].

作者信息

Ikebe S, Yokochi F, Wada T, Arakawa A, Mori H, Suda K, Kondo T, Mizuno Y

机构信息

Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.

出版信息

No To Shinkei. 1993 Oct;45(10):981-90.

PMID:8268041
Abstract

We report a 66-year-old man with progressive spinal paraplegia. He was well until June of 1991 when he had an onset of backache and right chest pain. On August 25, he lost sensation to void and he became unable to urinate. On the same day, he noted weakness in his legs which became progressively worse, and he was admitted to our hospital. Past medical history included diabetes mellitus which was found 3 years previously. He had upper gastrointestinal series 2 months before, which revealed a normal study. On admission, he was alert and general physical examination was unremarkable. Neurological examination revealed a mentally sound man with normal higher cerebral functions. Cranial nerves were also intact. He was unable to walk. No muscle atrophy was noted, but he had moderate to marked (2/5) weakness in both legs. No ataxia was noted in the upper extremities. Jaw jerk was normal, however, deep reflexes in the upper extremities were decreased, and absent in the lower extremities Babinski sign was present bilaterally. All sensory modalities were diminished below the Th 6 dermatome. No meningeal sign was present. Emergency myelography was performed on the day of admission, which revealed complete block from the Th4 to Th8 segments. CSF taken at that time was xanthochromic, positive Queckenstedt test containing 1,133 mg/dl of protein, 54 mg/dl of sugar and 1/3 microliters of lymphocyte. On August 31, laminectomy was performed from Th5 to Th7. The spinal bones in this area was very fragile and hemorrhagic. A soft yellowish vascular-rich tissue was surrounding the spinal cord in the epidural space. Despite surgery his weakness in legs worsened, and he became paraplegic by September 10th. He became somnolent with disorientation to time. In the subsequent course, he developed metabolic acidosis on September 26. On September 28, he became anuric and hypotensive. He expired later on that day.(ABSTRACT TRUNCATED AT 400 WORDS)

摘要

我们报告一例66岁进展性脊髓性截瘫男性患者。1991年6月前他身体状况良好,之后开始出现背痛和右胸痛。8月25日,他出现排尿感觉丧失且无法排尿。同一天,他注意到双腿无力且逐渐加重,随后入住我院。既往病史包括3年前发现的糖尿病。2个月前他接受过上消化道造影检查,结果正常。入院时,他神志清醒,全身体格检查无异常。神经系统检查显示该男子精神状态良好,高级脑功能正常。颅神经也完整。他无法行走。未发现肌肉萎缩,但双腿有中度至重度(2/5)无力。上肢未发现共济失调。下颌反射正常,然而上肢深反射减弱,下肢深反射消失,双侧巴氏征阳性。所有感觉模式在胸6皮节以下均减退。未出现脑膜刺激征。入院当天进行了紧急脊髓造影,结果显示胸4至胸8节段完全梗阻。当时采集的脑脊液呈黄色,奎肯施泰特试验阳性,蛋白含量为1133mg/dl,糖含量为54mg/dl,淋巴细胞为1/3微升。8月31日,进行了胸5至胸7椎板切除术。该区域的脊椎骨非常脆弱且有出血。硬膜外间隙有一个柔软的、富含血管的淡黄色组织包绕着脊髓。尽管进行了手术,他双腿的无力仍加重,到9月10日时发展为截瘫。他变得嗜睡,时间定向障碍。在随后的病程中,9月26日他出现代谢性酸中毒。9月28日,他无尿且血压降低。当天晚些时候死亡。(摘要截断于400字)

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