Göransson H
Department of Orthopaedics and Traumatology, University Central Hospital, Helsinki, Finland.
Arch Orthop Trauma Surg. 1993;112(5):232-5. doi: 10.1007/BF00451881.
Osteochondrogenic callus formation after delayed re-injury at different time intervals was evaluated. Twenty young rats were operated, and a standard bone defect reaching the medulla was sawn into the left hind leg. The rats were divided into two groups and the defect was re-created after 4 or 12 days. The rats were killed 7 or 14 days after the second operation. The developing new bone was revealed with a triple fluorochrome labelling system. The areas of bone and cartilage were measured histomorphometrically. The results suggested that an external factor, re-trauma, could increase both external and internal primary osteogenic callus formation. The optimum time to potentiate bone formation in the defects was found to be earlier than identified in previous fracture studies. After a 4-day delay the external callus was significantly larger than after the 12-day delay. Cartilage formation was not enhanced despite the sudden increase in osteogenic callus formation.
评估了在不同时间间隔延迟再损伤后骨软骨性骨痂的形成情况。对20只幼鼠进行手术，在左后腿锯出一个达髓质的标准骨缺损。将大鼠分为两组，在4天或12天后重新制造缺损。在第二次手术后7天或14天处死大鼠。用三重荧光染料标记系统显示正在形成的新骨。通过组织形态计量学测量骨和软骨的面积。结果表明，外部因素，即再次创伤，可增加外部和内部原发性骨痂的形成。发现增强缺损处骨形成的最佳时间比先前骨折研究中确定的时间更早。延迟4天后的外部骨痂明显大于延迟12天后的外部骨痂。尽管成骨痂形成突然增加，但软骨形成并未增强。
