Hernández Bermejo J P, Aguayo Albasini J L, Moreno Egea A, Martínez García P L, Zambudio Carmona G, Parrilla Paricio P
Laboratorio de Cirugía Experimental, Hospital Torrecárdenas, Almería.
Cir Pediatr. 1993 Jul;6(3):133-6.
The creation of intestinal neomucosa on grafts or materials implanted in the intestinal wall is one of the therapeutic procedures that has been tested in the short bowel syndrome. This paper presents the results obtained after intestinal implanting lyophilised dural patches in an experimental model of massive intestinal resection in rats. Data were contrasted with those of a control group subjected to massive resection without patches. The findings reveal: 1) high mortality related to the surgical technique; 2) slight improvement in the ponderal curve; 3) slowing down of intestinal transit; 4) neomucosa on the patch, with histological characteristic similar to normal. We conclude that although the creation of neomucosa on dural patches is feasible and conditions a slight improvement in the animal's nutritive status, application of the procedure is not practical in treatment for the short bowel syndrome due to the high mortality rate.
在植入肠壁的移植物或材料上形成肠道新黏膜是在短肠综合征中进行过测试的治疗方法之一。本文介绍了在大鼠大规模肠切除实验模型中植入冻干硬脑膜补片后的结果。将数据与未植入补片进行大规模切除的对照组的数据进行对比。研究结果显示：1）与手术技术相关的高死亡率；2）体重曲线略有改善；3）肠道运输减慢；4）补片上出现新黏膜，其组织学特征与正常情况相似。我们得出结论，尽管在硬脑膜补片上形成新黏膜是可行的，且能使动物营养状况略有改善，但由于高死亡率，该方法在短肠综合征治疗中并不实用。
