Lucas K G, Howrie D L, Phebus C K
Department of Pediatrics, Children's Hospital of Pittsburgh.
Pediatr Hematol Oncol. 1993 Jul-Sep;10(3):249-55. doi: 10.3109/08880019309029492.
A 2-year-old white female receiving multidrug chemotherapy for treatment of a primitive neuroectodermal tumor developed acute hypotension, bradycardia, and shock following administration of ondansetron and high-dose methylprednisolone. The subsequent clinical course is described, and cardiovascular reactions to ondansetron and methylprednisolone are reviewed. While the etiology of this severe reaction is uncertain, it is possible that it represents an idiosyncratic reaction to the rapid administration of high-dose adrenal corticosteroids. Patients receiving high-dose corticosteroid therapy should be closely monitored, and slow rates of infusion are recommended.
一名2岁白人女性因治疗原始神经外胚层肿瘤接受多药化疗，在给予昂丹司琼和大剂量甲泼尼龙后出现急性低血压、心动过缓和休克。描述了随后的临床病程，并回顾了对昂丹司琼和甲泼尼龙的心血管反应。虽然这种严重反应的病因尚不确定，但有可能是对快速给予大剂量肾上腺皮质类固醇的一种特异反应。接受大剂量皮质类固醇治疗的患者应密切监测，建议缓慢输注。
