土耳其安塔利亚地区的血红蛋白病
Hemoglobinopathies in the district of Antalya, Turkey.
作者信息
Bircan I, Sişli S, Güven A, Cali S, Yeğin O, Ertuğ H, Güven A G, Akar N
机构信息
Department of Pediatrics, Akdeniz University, Antalya, Turkey.
出版信息
Pediatr Hematol Oncol. 1993 Jul-Sep;10(3):289-91. doi: 10.3109/08880019309029499.
A screening program was conducted to ascertain the incidence of hemoglobinopathies in the district of Antalya, Turkey. The survey sample was selected from the household registration forms of health centers by systematic random sampling. Heparinized blood samples were collected from 1,616 subjects from 884 families. The prevalence of beta thalassemia traits with increased Hb A2 was 10.2%. This is higher than that found in previous studies performed in Antalya. The prevalence of abnormal hemoglobins (Hbs) was found to be 0.8%. Four subjects had Hb AS; five had Hb D-Los Angeles (B 121 [GH4] Glu-Gln); one had Hb Ube-2 (68 [E1] Ans-Asp), one had Hb P-Nilotic (fusion between B 22 and) and two had Hb D-like variants.
在土耳其安塔利亚地区开展了一项筛查计划，以确定血红蛋白病的发病率。通过系统随机抽样从健康中心的户籍表格中选取调查样本。从884个家庭的1616名受试者中采集了肝素化血样。血红蛋白A2升高的β地中海贫血特征的患病率为10.2%。这高于之前在安塔利亚进行的研究中发现的患病率。发现异常血红蛋白（Hb）的患病率为0.8%。4名受试者有血红蛋白AS；5名有血红蛋白D - 洛杉矶（B 121 [GH4] 谷氨酸 - 谷氨酰胺）；1名有血红蛋白Ube - 2（68 [E1] 谷氨酰胺 - 天冬氨酸），1名有血红蛋白P - 尼罗特（B 22与……之间的融合），2名有类似血红蛋白D的变体。
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