右心房起搏和硝酸甘油对动脉粥样硬化恒河猴的心电图影响。
Electrocardiographic effects of right atrial pacing and nitroglycerin in atherosclerotic rhesus monkeys.
作者信息
Lee R J, Lehner N D, Baky S H
出版信息
Eur J Pharmacol. 1976 Jun;37(2):237-40. doi: 10.1016/0014-2999(76)90030-3.
PMID:821759
Abstract
Right atrial pacing at rapid heart rates induced ischemic S-T segment changes in 19 atherosclerotic, male rhesus monkeys. Prior administration of nitroglycerin (100 mug/kg, i.v.) prevented the S-T segment alteration at a given pacing rate in 5 animals, attenuated it in 12 others, and had no effect in the remaining 2. The results of these studies are similar to earlier ones in atherosclerotic rabbits.
摘要
对19只患动脉粥样硬化的雄性恒河猴进行快速心率的右心房起搏，诱发了缺血性S-T段改变。预先静脉注射硝酸甘油（100微克/千克）后，5只动物在给定起搏速率下S-T段改变得到预防，12只动物的改变减轻，其余2只则无效果。这些研究结果与早期对动脉粥样硬化兔子的研究结果相似。
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