Warltier D C, Gross G J, Hardman H F
Eur J Pharmacol. 1975 Nov;34(1):229-32. doi: 10.1016/0014-2999(75)90244-7.
The direct effects or right atrial pacing and nitroglycerin on myocardial oxygen balance were studied in isolated canine hearts. Whereas atrial pacing produced an increase in myocardial oxygen consumption (MVO2) and no change in the affinity of hemoglobin for oxygen (P-50), an intracoronary infusion of nitroglycerin decreased both MVO2 and the affinity of hemoglobin for oxygen (increased P-50) in coronary venous blood. Under conditions of a constant coronary blood flow, nitroglycerin may benefit a hypoxic myocardium by reducing oxygen demand and by increasing availability of oxygen for rapid diffusion to tissue by increasing P-50.
在离体犬心研究了右心房起搏和硝酸甘油对心肌氧平衡的直接影响。心房起搏使心肌耗氧量（MVO2）增加，而血红蛋白对氧的亲和力（P-50）无变化，冠状动脉内输注硝酸甘油则使冠状静脉血中的MVO2和血红蛋白对氧的亲和力均降低（P-50升高）。在冠状动脉血流恒定的情况下，硝酸甘油可通过降低氧需求以及通过增加P-50来增加氧向组织快速扩散的可利用性，从而使缺氧心肌受益。
