de Iturri G C, Welsch C W
Experientia. 1976 Aug 15;32(8):1045-7. doi: 10.1007/BF01933963.
Explants derived from mammary carcinomas of DMBA-treated female Sprague-Dawley rats were cultured for 5 days in Medium 199 containing insulin and corticosterone. The addition of ovine prolactin to the culture media resulted in a consistent significant increase in H3-thymidine incorporation into DNA. DNA synthesis of explants treated with either ovine or human growth hormone was intermediary to prolactin-treated cultures and control cultures. A combination of prolactin and human growth hormone often increased DNA synthesis above either hormone alone, suggesting a possible growth synergism between these peptides.
将源自经二甲基苯并蒽（DMBA）处理的雌性斯普拉格-道利大鼠乳腺癌的外植体，在含有胰岛素和皮质酮的199培养基中培养5天。向培养基中添加绵羊催乳素导致H3-胸腺嘧啶核苷掺入DNA的量持续显著增加。用绵羊生长激素或人生长激素处理的外植体的DNA合成处于催乳素处理的培养物和对照培养物之间。催乳素和人生长激素的组合常常使DNA合成增加至高于单独使用任何一种激素的水平，这表明这些肽之间可能存在生长协同作用。
