Aspegren K, Tropé C
Acta Pathol Microbiol Scand A. 1977 Jan;85A(1):57-62. doi: 10.1111/j.1699-0463.1977.tb03868.x.
The in vitro effect of prolactin and hydrocortisone, singly or in combination, on the DMBA-induced mammary tumour in the rat was investigated by organ cultures. Prolactin had a stimulating effect on the DNA synthesis in one out of five tumours. Hydrocortisone induced lobulo-alveolar differentiation but reduced the DNA synthesis or failed to affect it. The addition of prolactin to hydrocortisone did not alter this response. Virus induced rat sarcomas were studied as control tissue. Prolactin inhibited growth of one sarcoma. Hydrocortisone stimulated growth of sarcomas. The relevance of these findings in relation to similar in vitro experiments is discussed.
通过器官培养研究了催乳素和氢化可的松单独或联合使用对二甲基苯蒽（DMBA）诱导的大鼠乳腺肿瘤的体外作用。催乳素对五分之一的肿瘤中的DNA合成有刺激作用。氢化可的松诱导小叶-腺泡分化，但减少了DNA合成或未对其产生影响。在氢化可的松中添加催乳素并未改变这种反应。研究病毒诱导的大鼠肉瘤作为对照组织。催乳素抑制了一种肉瘤的生长。氢化可的松刺激了肉瘤的生长。讨论了这些发现与类似体外实验的相关性。
