Eldering J A, Nay M G, Hoberg L M, Longcope C, McCracken J A
Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545.
Biol Reprod. 1993 Oct;49(4):809-15. doi: 10.1095/biolreprod49.4.809.
To study the hormonal regulation of prostaglandin (PG) production by the endometrium during the luteal phase of the primate menstrual cycle, the standard artificial menstrual cycle (SAMC) of the rhesus monkey was manipulated (MAMC) such that in one group of monkeys, there was an absence of the mid-cycle peak of estradiol-17 beta (E), but normal luteal phase progesterone (P). In the second group, there was a mid-cycle peak of E, but no luteal phase P. The accumulation of PGF2 alpha in tissue culture medium from explants of endometrium obtained on cycle Day 14 or 23 of the MAMC was compared to the accumulation of PGF2 alpha from explants on cycle Day 14 or 23 of the SAMC (expressed as mean ng +/- SEM/mg/24 h). Omission of the mid-cycle E peak in the MAMC did not alter endometrial PGF2 alpha production in vitro on cycle Day 14, compared to the SAMC; whereas, on cycle Day 23 PGF2 alpha, production was reduced (35.1 +/- 6.4 ng/mg/24 h), compared to that in the SAMC (53.8 +/- 10.3 ng/mg/24 h; p = 0.06). Omission of P during the MAMC resulted in higher PGF2 alpha production in vitro on cycle Day 14 (p < 0.01) and lower PGF2 alpha production on cycle Day 23 (p = 0.05), compared to that in the SAMC on these days.(ABSTRACT TRUNCATED AT 250 WORDS)
为研究灵长类动物月经周期黄体期子宫内膜前列腺素（PG）产生的激素调节，对恒河猴的标准人工月经周期（SAMC）进行了处理（MAMC），使得一组猴子缺乏雌二醇 - 17β（E）的周期中期峰值，但黄体期孕酮（P）正常。在第二组中，有E的周期中期峰值，但没有黄体期P。将在MAMC周期第14天或23天获得的子宫内膜外植体在组织培养基中PGF2α的积累与SAMC周期第14天或23天外植体中PGF2α的积累进行比较（表示为平均ng +/- SEM/毫克/24小时）。与SAMC相比，MAMC中省略周期中期E峰值在周期第14天并未改变体外子宫内膜PGF2α的产生；然而，在周期第23天，与SAMC（53.8 +/- 10.3 ng/毫克/24小时；p = 0.06）相比，PGF2α的产生减少（35.1 +/- 6.4 ng/毫克/24小时）。与这些日子的SAMC相比，MAMC期间省略P导致在周期第14天体外PGF2α产生增加（p < 0.01），在周期第23天PGF2α产生减少（p = 0.05）。（摘要截断于250字）
