Tangri S, Raghupathy R
Immunogenetics Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
Biol Reprod. 1993 Oct;49(4):850-6. doi: 10.1095/biolreprod49.4.850.
It is clear that the immune system and the reproductive system interact with and influence each other and that the immune system can have positive and negative regulatory effects on the outcome of pregnancy. The discovery of murine models of immunologically mediated spontaneous fetal resorptions has proved to be very useful for the study of immunological influences on pregnancy. In an attempt to elucidate the mechanisms underlying pregnancy impairment in one such "natural" model of pregnancy loss, we compared the expression of the cytokines tumor necrosis factor alpha, interferon tau, and interleukin-2 in placental tissue from a resorption-prone strain combination with the expression from a normal combination. We found significantly enhanced expression of these three cytokines in placentas from the resorption-prone combination using dot-blot hybridization and Northern hybridizations. Since these cytokines are abortifacients in vivo and have detrimental effects on the placenta, and hence on fetal development and survival, our demonstration of enhanced expression of these deleterious cytokines may give insight into the mechanisms involved in immunologically mediated spontaneous abortions.
很明显，免疫系统和生殖系统相互作用并相互影响，而且免疫系统对妊娠结局可产生正负调节作用。事实证明，免疫介导的自发性胎儿吸收的小鼠模型对于研究免疫对妊娠的影响非常有用。为了阐明在一种这样的“自然”流产模型中妊娠受损的潜在机制，我们比较了易发生吸收的品系组合的胎盘组织中细胞因子肿瘤坏死因子α、干扰素τ和白细胞介素-2的表达与正常组合的表达。我们通过斑点印迹杂交和Northern杂交发现，在易发生吸收的组合的胎盘中，这三种细胞因子的表达显著增强。由于这些细胞因子在体内是堕胎剂，并且对胎盘有有害影响，从而对胎儿发育和存活有有害影响，我们对这些有害细胞因子表达增强的证明可能有助于深入了解免疫介导的自然流产所涉及的机制。
