Asano M, Yoshida M, Omichi H, Mashimo T, Okabe K, Yuasa H, Yamanaka H, Morimoto S, Sakakibara H
Department of Material Development, Japan Atomic Energy Research Institute, Gunma.
Biomaterials. 1993 Aug;14(10):797-9. doi: 10.1016/0142-9612(93)90047-6.
A synthetic analogue of eel calcitonin, [Asu1, 7]-ECT, was incorporated into biodegradable poly(DL-lactic acids) with number-average molecular weights (Mn) of 1400-4400 by the melt-pressing technique. The in vitro release of drug from a parabolically degradable poly(DL-lactic acid) with Mn = 1400 showed an initial burst release and completed the release in 3 d from the start of the test. The drug release from a Mn = 4400 polymer with an S-type degradation pattern was kept at 14 +/- 5 units/d for an experimental period of 24 d.
鳗鱼降钙素的合成类似物[Asu1, 7]-ECT通过熔融压制技术被掺入数均分子量（Mn）为1400 - 4400的可生物降解聚（DL-乳酸）中。Mn = 1400的抛物线型可降解聚（DL-乳酸）的药物体外释放呈现出初始突释，并在试验开始后3天内完成释放。Mn = 4400且具有S型降解模式的聚合物的药物释放在24天的实验期内保持在14±5单位/天。
