Scelsi R, Poggi P, Lo Russo R, De Fabritiis F
Department of Human Pathology, University of Pavia, Italy.
In Vivo. 1993 Jul-Aug;7(4):353-5.
Dynamic cardiomyoplasty is based upon the use of electrostimulated Latissimus Dorsi muscle (LDM) to reinforce the ventricular wall of heart in patients with end-stage heart failure. In the present study we induced a preoperative reinforcement of LDM in 3 male patients selected for cardiomyoplasty, by means of a physiokinesiologic training. The application of morphometric techniques was useful to analyze the modifications in fibre type diameter and composition, in number and distribution of mitochondria and in number of capillaries in LDM needle biopsies performed before and after training. The preoperative muscle training induces trophic modifications in muscle fibres with increase in fibre diameter, in capillarity and in number and size of mitochondria. These parameters indicate that a preoperative training of LDM before cardiomyoplasty may be useful for muscle reinforcement and for preparation to the electrostimulation program in the postoperative cardiac assistance.
动力性心肌成形术是基于使用电刺激的背阔肌（LDM）来增强终末期心力衰竭患者的心室壁。在本研究中，我们通过生理运动训练对3名入选心肌成形术的男性患者术前强化LDM。形态计量学技术的应用有助于分析训练前后LDM针吸活检中纤维类型直径和组成、线粒体数量和分布以及毛细血管数量的变化。术前肌肉训练可诱导肌纤维发生营养性改变，纤维直径、毛细血管密度以及线粒体数量和大小增加。这些参数表明，心肌成形术前对LDM进行术前训练可能有助于肌肉强化以及为术后心脏辅助的电刺激程序做准备。
